Our paper looking at the link between PGC-1alpha and inflammatory signaling in hepatocytes is out in Molecular Metabolism! A new function for a short form of the canonical protein.
Times have changed considerably and we are adapting day-by-day to the challenges posed by Covid-19. Currently, our lab is closed. We are looking forward to the time when we can restart our research on metabolic disease.
In the meantime, I want to commend the dedicated members of my lab who are remaining strong through this crisis. We will get through this together.
A huge congratulations to Dr. Mélissa Léveillé, who successfully defended her doctoral thesis on March 25th! She did an amazing job at her virtual defence, one of only many challenges Mélissa faced during her PhD training. We are all so proud!!
Congratulations to Hannah Zhang for winning best Pitch Talk at the MDRC Annual Scientific Day. Also many thanks to Diabetes Quebec for funding our lab to create a new mouse model to study beta cell function!
Congratulations to Mélissa Léveillé for receiving the Montreal Diabetes Research Centre Travel Award, and Hannah Zhang for receiving the Graduate Research Enhancement & Travel (GREAT) Award from McGill and the Keystone Symposia Future of Science Fund scholarship! They will be attending the Keystone meeting on Obesity and NAFLD: Mechanisms and Therapeutics in Banff in February 2020!
Are you a BSc or MSc student looking for a place to continue your studies? Click here to find out more about available positions in our lab and how to apply. Would you like to try out the lab beforehand? Eligible students can apply for a paid winter, spring or summer internship prior to starting the degree program.
We are trying preprints for the first time. Check out our new work available on BioRxiv about PGC-1A4 – this was an amazing group effort by many lab members over many years. 10 years in the making, many collaborations and lots of minds working together.
Another successful retreat for the IRCM at Estrimont this year. My lab
sweeped the competition by winning 3 prizes for best posters and oral presentations. Congrats to Emilie, Philipa and Mélissa for their wins! Can you spot us all in the picture?
May was a busy month! We were lucky to have some press coverage of our recent work in the media – seems we have a lot more to learn about the role of glucagon in the control of blood glucose. (RadioCanada)
I was honoured to be invited to speak at this year’s Pint-Of-Science in Montreal. It was a great night and a fun venue. I recommend these events to anyone who wants to find out what scientists do, ask questions about their work, and simply to have a pint with cool people.
Thank you to all the generous donors who supported our team in the IRCM Challenge! We raised $2850 this year and braved the cold, rainy weather to all finish the race. Well done Anti-Diabetic Agents!!
Congratulations to Hannah Zhang, an undergrad trainee in my lab who was just awarded the prestigious CGS – Master’s Award for her graduate work in our lab, starting in the Fall – wish her luck!
An interesting article in La Presse+ discussing our recent discovery linking PGC-1A and hepatic insulin signaling. Encouraging words that we should think about glucagon (and PGC-1alpha) differently in the context of diabetes.
The Estall Lab was excited to be a part of the A-BC Islet Workshop this year in snowy Kelowna, BC! Great 2 days of science and networking (and my bowling score improved 10-fold over last year).
Hot off the press! We just published a paper in PNAS showing that PGC-1 in liver is important for regulating blood glucose levels, in more ways than expected. Seems PGC-1alpha, downstream of glucagon, controls the IRS1:IRS2 ratio to help insulin to shut down hepatic glucose output right after a meal.
Check out the work by our team here: PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
Look who won prizes for best poster at the MDRC Annual Retreat!! Congratulations to Philipa (MSc student) and Stewart (Post-Doc). As per tradition, drinks were on them that night…
Mélissa gearing up for her “Pitch Talk” at the MDRC annual Retreat on whether we should care about PGC-1alpha levels in liver cancer linked to obesity. She did a great job convincing us we should!
Happy New Year everyone! To escape the wintery weather, we had our first ever lab curling event. Although we were all rookies, we were surprisingly good!
Congratulations Philipa for being awarded the JA DeSeve Excellence Scholarship from the FESP!
A warm welcome to Yeliz Yilmaz (an exchange PhD student) and Dr. Aysim Gunes (a post-doctoral fellow) from Turkey (Dokuz Eylül University), both coming to learn the metabolic side of liver cancer linked to obesity. We are also looking forward to learning about cellular mechanisms of liver cancer from them, in collaboration with Drs. Nese Atabey and Mehmet Ozturk.
Congratulations to our own Dr. Stewart Jeromson for being awarded a prestigious Post-doc Fellowship from Diabetes Canada. Well-deserved! And many thanks to Diabetes Canada for their continued support of our research.
In an article published in Montréal InVivo, Philipa talks about her unconventional start in Molecular Biology and how that path led her to our lab as a graduate student!
Thanks to pioneering work done by the Larose Lab, we are now embarking on understanding whether Nck proteins can or should be targeted to treat diabetes. Here is the first published work on this – a collaborative effort opening a new chapter in the Estall Lab.
Congratulations to the now Dr. Aurèle Besse-Patin, who successfully defended his PhD and passed with flying colours!
Woohoo! Philipa has won a Master’s scholarship from the MDRC for her work on hepatokines secreted from fatty liver.
It was great to catch up with the Canadian (and the token brit) beta cell experts at the A-BC Islet Workshop in Kelowna, BC. I learned many new things (and confirmed that bowling is not my forté).
We’ve had a busy winter! Hope you had a chance to see Philipa give her talk at the recent Organ Crosstalk in Obesity and NAFLD Keystone meeting in Colorado. If not, stay tuned for more about liver hepatokines and diabetes in the future from the Estall Lab.
Ever wonder if mutations of PGC-1α are linked to metabolic disease and why? Read our paper reviewing the basic and clinical research on one particular mutation and diabetes. Thanks to Roxy and Naveen for the hard work putting it together!
Many thanks to the CIHR and the IDRC for funding our international, collaborative project with Drs. Eithan Galun (Israel) and Mehmet Ozturk (Turkey) on NASH-related HCC.
Wearing blue to raise awareness to Diabetes Awareness Month! World Diabetes day is on November 14. Diabetes affects millions of people worldwide, and many don’t even know it yet!
Congratulations to Stewart Jeromson for obtaining a post-doctoral fellowship from the IRCM! Now you only have to successfully defend your PhD in a few weeks to get it – No pressure 🙂
Another travel award for Aurèle Besse-Patin for his work on sex and NASH! Thanks to the MDRC for their continued support for own lab.
We sometimes get out to rest too, trust me 🙂 After a good afternoon of team building in escape rooms, we got to chill by a roof-top pool before going out.
And she’s back! We somehow convinced Philipa Levesque-Damphousse to return after her internship last summer to complete her Master’s degree. Welcome back to our team and looking forward to seeing her projects develop on novel hepatokines in diabetes.
My students are on fire this year! Both Roxy and Aurèle won prizes for best poster and oral presentations at IRCM research day.
Drinks were definitely on them that night 🙂
Congratulations to my amazing lab team, The Anti-Diabetic Agents, for raising $2163 for the IRCM challenge run this year! It was a great day and the rain held off just long enough for us to enjoy it 🙂 Very proud of all my current (and future) team members who participated, completing the race pushing carriages, wearing costumes, and on sprained ankles!
Roxy took the stage at the Boston/Ithica Islet Club meeting in New Haven, Connecticut to represent our lab and present her Master’s project. She did an awesome job!
Is nutrient metabolism in the cells of the pancreas important for whole body energy homeostasis? Of course! Check out Nathalie’s review highlighting current breakthroughs in this area.
Jouvet N, Estall JL. Experimental Cell Research 2017
And here he is in full force representing the Estall Lab in Lake Tahoe. We heard a lot about sex at this meeting!
Congrats also to Aurèle for the scholarship to present his work!
“Estrogen signals through PGC-1α to reduce oxidative stress associated with diet-induced fatty liver disease”. His talk is Tuesday, March 21st at 2:30pm!
Presentation/Poster winners at the Annual MDRC Retreat. Look who’s standing at the right-hand side. Congrats Aurèle!
Congratulations to Roxy for winning a travel award from McGill for the Keystone meeting! She represented the lab well and stimulated lots of interesting discussion about the biology of a diabetes-related SNP.
Poster #: 3021
The molecular basis of increased diabetes susceptibility in carriers of the PGC-1α (Ser482) risk allele
A big welcome to Stewart Jeromson, our new post-doc coming from across the pond (University of Stirling, Scotland). Hopefully the Canadian winter will treat him well!
Cool blog talking about the importance of including females in biomedical research (including a quote from yours truly)!
Very proud to have our own Aurèle Besse Patin win the IRCM Prix D’Excellence (André Barbeau) = Best Student of the YEAR!
Mélissa gets yet another scholarship from the University of Montreal! Soon she will make more than me 🙂
Our comments on why mice are such amazing metabolic creatures.
Do mouse beta cells resist aging??
Jouvet N, Estall JL. Endocrinology 2016
Fresh off the press! Estrogen’s ability to protect against oxidative stress in mouse liver caused by high fat/sugar diets requires PGC-1alpha – And, you may carry a gene variant that decreases its expression! Read all about it in our recently published paper in Gastroenterology.
Many congrats to Roxy for winning the Ethelwyn and Ernie Nyman Bursary from McGill University! The first of many accolades to come.
Aurèle was on the radio talking about our latest projects to look at the effect of sex on metabolic disease and the drugs to treat it (Radio-Canada: Les Années lumière).
Importance of comparing both sexes in research on metabolic disease! We are missing a lot….
Article in the Montreal Metro about our research to look at this with FGF21 discusses some concerning issues. Funded by a Catalyst grant from the CIHR!
My lab at the 2016 IRCM Forum – Great meeting and love the new format!
Mélissa is on a role! A PhD scholarship from Diabetes Québec and Best Poster Prize at the Journée Scientifique de Biologie Moléculaire, UdeM!! Many congratulations!!
UPDATE: Thanks to the generosity of all of you, our team raised $1,825 for the 2016 IRCM Challenge Run on Mont Royal. Our team also won the trophy for the most money raised per team member!!
Please support our lab team, The Anti-Diabetic Agents, in our run to further biomedical research at the IRCM! Click here to make a donation, which goes directly to student training and disease research.
Congratulations to Mélissa for obtaining a competitive PhD scholarship from the Montreal Diabetes Research Centre!
Met great colleagues and collaborators (old and new) at the Keystone Symposia: Islet Biology from Cell Birth to Death in Keystone, CO
Another successful Annual MDRC Retreat! Can you spot my lab?
Another conference for Melissa! Come visit and chat with her at the upcoming Keystone Symposia: New Frontiers in Understanding Tumor Metabolism (Feb 21-25, 2016 Banff, Alberta)
Poster: The Role of PGC-1α in NAFLD-associated Liver Cancer
February was a busy month! Lots of conference presentations from my trainees:
Speaker: Mélissa Léveillé
Title: The role of PGC-1alpha in NAFLD-associated liver cancer Session I: Complications hépatiques de l’obésité When: Wednesday February 10, 9h45
Poster was also at CCWD 2016: Sunday
February 28, 18h-19h30
Speaker: Aurèle Besse-Patin
Title: Reduced hepatic PGC-1α leads to oxidative stress and worsened NAFLD progression Symposium II: Cardiomyopathie métabolique: la nouvelle face des maladies cardiovasculaires
When: Thursday February 11, 15
Speaker: Aurèle Besse-Patin
Title: Reduced hepatic PGC-1α leads to oxidative stress and worsened NAFLD progression
When: Sunday February 28, 9h00-10h30
Poster was also at Réunion Annuelle de la SQLNM, du CMDO et de COLosSU
Speaker: Dr. Cristina Bosoi (presenting work from her PhD with Dr. Chris Rose, CRCHUM)
Title: Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats
When: Saturday February 27, 8h30-10h00
Really nice commentary about our Diabetes paper in the current issue. Human Growth Hormone in Transgenesis: A growing problem?
Congratulations to Aurèle and Mélissa for their continued success in competitions for University of Montréal scholarships! Keep up the great work.
An official welcome to our new graduate student, Roxanne (Roxy) Vandenbeek! Although if you look carefully, she somehow found her way into the boat during our summer rafting trip.
We are happy to report that Daniel’s discovery of the role of PGC-1 co-activators in beta-cells has been published in Molecular
Metabolism! Nicely done, congrats to all and special thanks to all our collaborators.
Taking a much needed break from bench (and paper) work on the Rouge River.
Our discovery of STZ-resistance and hGH expression in the MIP-creERT mouse line was just published in Diabetes! Thanks to Daniel and Nathalie for the amazing effort.
Confused as to which Cre-driver to use for beta-cell research? Two new lines published in Endocrinology look promising. Check out our editorial on the subject.
June 5-9, 2015
Great poster session at the ADA Scientific Sessions 2015 in Boston, MA with Nathalie at the helm.
Make your voice heard! Join the discussion on recent changes to scientific funding in Canada – The more scientists they hear from, the better chance we have to come up with a plan for action.
May 9, 2015
Give a shout out to our lab (“The Anti-Diabetic Agents”) who raised over $2,800 for the IRCM Challenge Run this year.
Also, congratulations to Aurèle for winning the bronze medal in the 10 km race!
Congratulations to Mélissa for renewing her PhD scholarship from UdeM!
June 5-9, 2015
Come visit us during our late-breaking poster (LB-330) presentation at the American Diabetes Association (ADA) Scientific Sessions in Boston, MA.
Many congrats to Dr. Cristina Bosoi, our new post-doc, for obtaining the prestigious FRQS postdoctoral fellowship award!
Congratulations to Dr. Nathalie Jouvet for her Post-doc fellowship from the MDRC!
Congratulations to Naveen for winning the Best Poster Prize at the Annual McGill Biomedical Graduate Student Conference!!
Come chat with my lab at the Keystone Meeting in Whistler, BC – Joint Meetings of Liver Metabolism / NAFLD and Obesity, MetS, and Mitochondria.
Dual role for PGC-1α on hepatic insulin sensitivity through modulation of ROS and direct regulation of the insulin signalling pathway – Aurèle Besse-Patin
Pgc-1 Coactivators Are Required for Fatty-Acid-Potentiated Insulin Secretion and Appropriate Lipid Storage in Mature β-cells – Nathalie Jouvet
Special congrats to Nathlie for winning a Keystone Scholarship to attend the meeting!
@ Colossus / SQLNM / CMDO 2015
Come see me and Nathalie Jouvet give talks on our recent work defining the role of Pgc-1, lipid metabolism, and mitochondria in beta-cell function.
Hotel Chéribourg, Magog-Orford, QC – February 17-19, 2015
February 6, 2015
MDRC 9th Annual Retreat
Great to be a part of an amazing line-up of speakers including Drs. Philip Scherer and Ralph DeFronzo.
Guess who’s now a Doctor! Daniel passed his PhD defence with flying colours and now rightfully deserves the title of Dr. Oropeza.
(He was cool as always, even with so much stress – the exam was almost cancelled because of a snowstorm!!)
Special thanks to Dr. Jamie Joseph, Daniel’s external, for braving the weather to be here.
Congratulations to Aurèle for yet another scholarship from the University of Montreal! Guess who’s buying us all lunch….
PhD Scholarship, Molecular Biology – University of Montreal
Congratulations to Mélissa for her first scholarship as a PhD student in our lab!
Accelerated Passage from Master’s to PhD program, Molecular Biology – University of Montreal
We were just awarded 2 grants for our work investigating altered liver metabolism, fatty liver disease, and cancer.
Many thanks to the funding agencies for supporting our research and my trainees for providing preliminary data.
Canadian Liver Foundation (CLF) and the Canadian Institutes of Health Research (CIHR)
2014 – 2015
Aurèle Besse-Patin is on a roll! – he recently received a PhD scholarship from the IRCM!
Welcome our two summer interns: Wulan Chen (McMaster University) and Noura Kabbara (UQÀM).
Congratulations to Aurèle for receiving a travel award from the University of Montreal for his Keystone conference presentation!
Our lab attended the MDRC Annual Retreat this year in Montreal. Hope you had a chance to visit our posters.
January 15, 2014
Our paper in AJP received some media coverage!
Come meet me and my lab members at the upcoming Keystone Symposia: Challenges and Opportunities in Diabetes Research and Treatment in Vancouver, BC.
We are presenting our work at Workshop 1 on January 13th.
Or drop by our two posters:
1) Role of beta-cell mitochondrial dysfunction in the development of diabetes – Daniel Oropeza
2) Loss of PGC-1alpha expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation – Aurèle Besse-Patin
Check our our review article on new roles of ROS in regulating hepatic insulin sensitivity in NAFLD:
An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease
Aurèle Besse-Patin and Jennifer L. Estall
January 06, 2014
Welcome to our new team member Nathalie Jouvet!
She started her post-doctoral training in our lab in January.
We published our first paper! Congratulations to all authors and lab members and special thanks for the hard work.
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL.
Am J Physiol Endocrinol Metab. 2013 Nov 26. [Epub ahead of print] PMID: 24280126
Congratulations to Melissa Leveille for her new scholarship!
Master’s Scholarship, Molecular Biology – University of Montreal
Congratulations to Aurèle for his new scholarship!
PhD Scholarship, Molecular Biology – University of Montreal
August 15, 2013
Please congratulate Sarah Sczelecki, for successfully completing her Master’s degree in the Estall Lab!
August 12, 2013
Welcome to our new team member Naveen Perwaiz Khan!
She is starting a Master’s degree in our lab.
Congratulations to Aurèle for his poster award!
Prix Richard Rabasa-Lhoret, IRCM Student Research Day 2013
Title: Development of a mouse model for fatty liver disease
Congratulations to Daniel for his poster award!
Best poster, Montreal Diabetes Research Centre Retreat 2013
Title: Function of PGC1 proteins in beta cells and its implication in Diabetes
Congratulations to Daniel for his travel award from the Department of Anatomy and Cell Biology, McGill University!
Congratulations to Sarah for her poster award!
Prix Richard Rabasa-Lhoret, IRCM Student Research Day 2012
Title: Understanding the function of PGC-1alpha isoforms in beta cell’s survival and diabetes.
Café Scientifique at the IRCM
Presentation by Dr. Jennifer Estall – Type-1 diabetes: towards a needle-free future
View the video of the conference on our YouTube Channel.
The Estall Lab is official opened at the Institut de recherches cliniques de Montreal.
Jen and Alexandra Abboud (research assistant and lab manager) christen the *temporary lab with all the new equipment.
*the lab moves 2 times more before settling on the 2nd floor at the end of 2012. I definitely miss the view of the mountain from the 7th floor!
Big dreams get a head start – article on Dr. Estall following up on the H.L. Holmes Award from the National Research Council of Canada.
Article published by the NRC
H.L. Holmes Award – Presented and given to Dr. Jennifer Estall
Dr. Estall received this funding to support her post-doctoral training with Dr. Bruce Spiegelman’s Lab (Harvard Medical School, Boston, USA).
Articles published by the NRC: