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March 2017

Keystone-symposia-top_logoHope to see you all at the Keystone Symposia: Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and
Obesity
March 19 – 22, 2017 | Tahoe City, California, USA

Congrats also to Aurèle for the scholarship to present his work!
“Estrogen signals through PGC-1α to reduce oxidative stress associated with diet-induced fatty liver disease”


January 2017

Keystone-symposia-top_logoBe sure to chat with Roxy Vandenbeek in Colorado, representing our lab at Keystone Symposia: Diabetes, from January 22 – January 26, 2017.

Poster #: 3021
The molecular basis of increased diabetes susceptibility in carriers of the PGC-1α (Ser482) risk allele


December 2016_dsc1851

Very proud to have our own Aurèle Besse Patin win the IRCM Prix D’Excellence (André Barbeau)  = Best Student of the YEAR!

 


November 2016logo-udem

Mélissa gets yet another scholarship from the University of Montreal!  Soon she will make more than me 🙂


September 2016

Fresh off the press! Estrogen’s ability to protect against oxidative stress in mouse liver caused by high fat/sugar diets requires PGC-1alpha – And, you may carry a gene variant that decreases its expression! Read all about it in our recently published paper in Gastroenterology.

Estrogen Signals through PPARG coactivator 1 alpha to Reduce Oxidative Damage Associated with Diet-induced Fatty Liver Disease


August 2016

Many congrats to Roxy for winning the Ethelwyn McGill-University-Logo-300x70
and Ernie Nyman Bursary 
from McGill University! The first of many accolades to come.


August 2016

Aurèle was on the radio talking about our latest projects to look at the effect of sex on metabolic disease and the drugs to treat it (Radio-Canada: Les Années lumière).

Les oubliées de la recherche – Reportage de Marianne Desautels-Marissal


July 2016

CIHR-logoImportance of comparing both sexes in research on metabolic disease! We are missing a lot….

Article in the Montreal Metro about our research to look at this with FGF21 discusses some concerning issues. Funded by a Catalyst grant from the CIHR!


July 2016

diabetequebec_en_logoA big thanks to Diabetes Quebec for their continued support of our lab. A new research grant to support our work on genetic influences on diabetes risk


June 2-3, 201613346356_10154239530357299_4040646517742400931_o

My lab at the 2016 IRCM Forum – Great meeting and love the new format!

 


May, 2016diabetequebec_en_logo

Mélissa is on a role! A PhD scholarship from Diabetes Québec and Best Poster Prize at the Journée logo-udemScientifique de Biologie Moléculaire, UdeM!! Many congratulations!!


May 7, 2016IMG_1688

UPDATE: Thanks to the generosity of all of you, our team raised $1,825 for the 2016 IRCM Challenge Run on Mont Royal. Our team also won the trophy for the most money raised per team member!!


May, 2016

Please support our lab team, The Anti-Diabetic Agents, in our run to further biomedical research at the IRCM! Click here to make a donation, which goes directly to student training and disease research.
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April, 2016

logo_mdrc-3-300x52Congratulations to Mélissa for obtaining a competitive PhD scholarship from the Montreal Diabetes Research Centre!


March, 2016

Keystone-symposia-top_logoMet great colleagues and collaborators (old and new) at the Keystone Symposia: Islet Biology from Cell Birth to Death in Keystone, CO


 

photo retraite 2016 finaleFebruary, 2016

Another successful Annual MDRC Retreat! Can you spot my lab?

 


February, 2016

Another conference for Melissa!  Come visit and chat with her at the upcoming Keystone Symposia: New Frontiers in Understanding Tumor Metabolism (Feb 21-25, 2016 Banff, Alberta)Keystone-symposia-top_logo

Poster: The Role of PGC-1α in NAFLD-associated Liver Cancer


February, 2016

February was a busy month! Lots of conference presentations from my trainees:

logo_SQLNM_smallRéunion Annuelle de la SQLNM, du CMDO et de COLosSUS

 

Speaker: Mélissa Léveillé
Title: The role of PGC-1alpha in NAFLD-Melissa SQLMNassociated liver cancer Session I: Complications hépatiques de l’obésité When: Wednesday February 10, 9h45
Poster was also at CCWD 2016:  Sunday
February 28, 18h-19h30

 

Aurele SQLNMSpeaker: Aurèle Besse-Patin
Title: Reduced hepatic PGC-1α leads to oxidative stress and worsened NAFLD progression

Symposium II: Cardiomyopathie métabolique: la nouvelle face des maladies cardiovasculaires
When: Thursday February 11, 15h

Canadian Digestive Diseases Week (CDDW 2016)

Speaker: Aurèle Besse-Patincddw-2016-257x201
Title: Reduced hepatic PGC-1α leads to oxidative stress and worsened NAFLD progression
When: Sunday February 28, 9h00-10h30
Poster was also at Réunion Annuelle de la SQLNM, du CMDO et de COLosSU

Speaker: Dr. Cristina Bosoi (presenting work from her PhD with Dr. Chris Rose, CRCHUM)
Title: Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats 
When: Saturday February 27, 8h30-10h00


November, 2015

Really nice commentary about our Diabetes paper in the current issue. Human Growth Hormone in Transgenesis: A growing problem?


October, 2015

logo-udemCongratulations to Aurèle and Mélissa for their continued success in competitions for University of Montréal scholarships!  Keep up the great work.


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September, 2015

An official welcome to our new graduate IMG_4640student, Roxanne (Roxy) Vandenbeek! Although if you look carefully, she somehow found her way into the boat during our summer rafting trip.

 


August, 2015

We are happy to report that Daniel’s discovery of the role of PGC-1 co-activators in beta-cells has been published in Molecular
Metabolism! Nicely done, congrats to all and special thanks to all our collaborators.

PGC-1 coactivators regulate lipid metabolism in beta-cells and are essential for insulin secretion coupled to fatty acids


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August, 2015

Taking a much needed break from bench (and paper) work on the Rouge River.

#LabOuting2015


July 2015

Our discovery of STZ-resistance and hGH expression in the MIP-creERT mouse line was just published in Diabetes! Thanks to Daniel and Nathalie for the amazing effort.

Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone


July 2015

Confused as to which Cre-driver to use for beta-cell research? Two new lines published in Endocrinology look promising. Check out our editorial on the subject.


Nathalie ADAJune 5-9, 2015

Great poster session at the ADA Scientific Sessions 2015 in Boston, MA with Nathalie at the helm.

 


June, 2015

Make your voice heard!  Join the discussion on recent changes to scientific funding in Canada – The more scientists they hear from, the better chance we have to come up with a plan for action.

The Future of Canadian Science


May 9, 2015

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Give a shout out to our lab (“The Anti-Diabetic Agents”) who raised over $2,800 for the IRCM Challenge Run this year.

Also, congratulations to Aurèle for winning the bronze medal in the 10 km race!

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May, 2015

logo-udemCongratulations to Mélissa for renewing her PhD scholarship from UdeM!


June 5-9, 2015

Come visit us during our late-breaking poster (LB-330) presentation at the American Diabetes Association (ADA) Scientific Sessions in Boston, MA.


April, 2015FRSQ-Logo

Many congrats to Dr. Cristina Bosoi, our new post-doc, for obtaining the prestigious FRQS postdoctoral fellowship award!


April, 2015

logo_mdrc-3-300x52Congratulations to Dr. Nathalie Jouvet for her Post-doc fellowship from the MDRC!


IMG_20150319_171541March, 2015

Congratulations to Naveen for winning the Best Poster Prize at the Annual McGill Biomedical Graduate Student Conference!!


March, 2015

Come chat with my lab at the Keystone Meeting in Whistler, BC – Joint Meetings of Liver Metabolism / NAFLD and Obesity, MetS, and Mitochondria.

Check out our posters while enjoying a glass of wine:Keystone-symposia-top_logo

Dual role for PGC-1α on hepatic insulin sensitivity through modulation of ROS and direct regulation of the insulin signalling pathway – Aurèle Besse-Patin

Pgc-1 Coactivators Are Required for Fatty-Acid-Potentiated Insulin Secretion and Appropriate Lipid Storage in Mature β-cells – Nathalie Jouvet

Special congrats to Nathlie for winning a Keystone Scholarship to attend the meeting!


February, 2015IMG_0877

Nathalie’s Talk
@ Colossus / SQLNM / CMDO 2015

 


February, 2015

Come see me and Nathalie Jouvet give talks on our recent work defining the role of Pgc-1, lipid metabolism, and mitochondria in beta-cell function.

logo_SQLNM_small LogoCMDO_Complet_Rouge@ Colossus / SQLNM / CMDO 2015

Hotel Chéribourg, Magog-Orford, QC – February 17-19, 2015


February 6, 2015

MDRC 9th Annual Retreatlogo_mdrc-3-300x52

Great to be a part of an amazing line-up of speakers including Drs. Philip Scherer and Ralph DeFronzo.

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@CRCHUM


December, 2014

McGill-University-Logo-300x70Guess who’s now a Doctor! Daniel passed his PhD defence with flying colours and now rightfully deserves the title of Dr. Oropeza.

(He was cool as always, even with so much stress – the exam was almost cancelled because of a snowstorm!!)

Special thanks to Dr. Jamie Joseph, Daniel’s external, for braving the weather to be here.


October, 2014

logo-udem

Congratulations to Aurèle for yet another scholarship from the University of Montreal! Guess who’s buying us all lunch….

PhD Scholarship, Molecular Biology – University of Montreal


September, 2014

logo-udem

Congratulations to Mélissa for her first scholarship as a PhD student in our lab!

Accelerated Passage from Master’s to PhD program, Molecular Biology – University of Montreal


July, 2014

We were just awarded 2 grants for our work investigating altered liver metabolism, fatty liver disease, and cancer.

CIHR-logoCLF logo

Many thanks to the funding agencies for supporting our research and my trainees for providing preliminary data.

Canadian Liver Foundation (CLF) and the Canadian Institutes of Health Research (CIHR)


2014 – 2015Untitled-2

Aurèle Besse-Patin is on a roll! – he recently received a PhD scholarship from the IRCM!


May, 2014

Welcome our two summer interns: Wulan Chen (McMaster University) and Noura Kabbara (UQÀM).


March, 2014

Check out the article in *catalyst highlighting our research!

Muscle protein linked to diabetes risk


March, 2014logo-udem

Congratulations to Aurèle for receiving a travel award from the University of Montreal for his Keystone conference presentation!


February 07, 2014
logo_mdrc-3-300x52

Our lab attended the MDRC Annual Retreat this year in Montreal.  Hope you had a chance to visit our posters.


January 15, 2014

Our paper in AJP received some media coverage!

Radio-Canada, GlobeAdvisor, Journal Métro, and Huffington Post.


January 12-19, 2014Keystone-symposia-top_logo

Keystone Symposia

Come meet me and my lab members at the upcoming Keystone Symposia: Challenges and Opportunities in Diabetes Research and Treatment in Vancouver, BC.

We are presenting our work at Workshop 1 on January 13th.

Or drop by our two posters:

1) Role of beta-cell mitochondrial dysfunction in the development of diabetes – Daniel Oropeza

2) Loss of PGC-1alpha expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation – Aurèle Besse-Patin


January, 2014

Check our our review article on new roles of ROS in regulating hepatic insulin sensitivity in NAFLD:

An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease
Aurèle Besse-Patin and Jennifer L. Estall


January 06, 2014

Welcome to our new team member Nathalie Jouvet!

She started her post-doctoral training in our lab in January.


November, 2013

We published our first paper!  Congratulations to all authors and lab members and special thanks for the hard work.

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL.

Am J Physiol Endocrinol Metab. 2013 Nov 26. [Epub ahead of print]  PMID: 24280126


2013-2014logo-udem

Congratulations to Melissa Leveille for her new scholarship!

Master’s Scholarship, Molecular Biology – University of Montreal


2013-2014logo-udem

Congratulations to Aurèle for his new scholarship!

PhD Scholarship, Molecular Biology – University of Montreal


August 15, 2013McGill-University-Logo-300x70

Please congratulate Sarah Sczelecki, for successfully completing her Master’s degree in the Estall Lab!


August 12, 2013

Welcome to our new team member Naveen Perwaiz Khan!

She is starting a Master’s degree in our lab.


May 2013

Congratulations to Aurèle for his poster award!

Prix Richard Rabasa-Lhoret, IRCM Student Research Day 2013

Title: Development of a mouse model for fatty liver disease


February 2013

Congratulations to Daniel for his poster award!

Best poster, Montreal Diabetes Research Centre Retreat 2013

Title: Function of PGC1 proteins in beta cells and its implication in Diabetes


January 2013McGill-University-Logo-300x70

Congratulations to Daniel for his travel award from the Department of Anatomy and Cell Biology, McGill University!


April 2012

Congratulations to Sarah for her poster award!

Prix Richard Rabasa-Lhoret, IRCM Student Research Day 2012

Title: Understanding the function of PGC-1alpha isoforms in beta cell’s survival and diabetes.


April 23, 2012YOUTUBEEE-300x156

Café Scientifique at the IRCM

Presentation by Dr. Jennifer Estall – Type-1 diabetes: towards a needle-free future

View the video of the conference on our YouTube Channel.


March, 2011

The Estall Lab is official opened at the Institut de recherches cliniques de Montreal.

Jen and Alexandra Abboud (research assistant and lab manager) christen the *temporary lab with all the new equipment.

*the lab moves 2 times more before settling on the 2nd floor at the end of 2012. I definitely miss the view of the mountain from the 7th floor!


April 01, 2010Print

Big dreams get a head start – article on Dr. Estall following up on the H.L. Holmes Award from the National Research Council of Canada.

Article published by the NRC

http://archive.nrc-cnrc.gc.ca/eng/news/nrc/2010/04/01/estall.html


October, 2007Print

H.L. Holmes Award – Presented and given to Dr. Jennifer Estall

Dr. Estall received this funding to support her post-doctoral training with Dr. Bruce Spiegelman’s Lab (Harvard Medical School, Boston, USA).

Articles published by the NRC:

http://archive.nrc-cnrc.gc.ca/eng/news/nrc/2007/10/07/diabetes-research.html

http://archive.nrc-cnrc.gc.ca/eng/news/nrc/2007/10/03/estall-holmes-awards.html